When superhero Rodissius got injured in battle, he had to be evacuated to Mighty Med Hopital. To save his life, Kaz and Oliver had to remove his powers. After realizing this, Rodissius swore vengeance against all superheroes. On June 12, 2016, Rodissius sent his sons Roman and Riker to destroy Mighty Med, thus killing many superheroes. After Kaz, Oliver, and Skylar learned about this, they contacted their allies Bree and Chase, and The Shapeshifter War began.
10 months later, when The Elite Force created the superhero list, Roman and Riker right away went for it. However, they failed due to the Elite Force wacthing them. Therefore, Rodissius gave them a plan to trick the Elite Force. However, the tide of the war was turned when Oliver, Bree, and Adam got ahead on Rodissius' plan. On March 27 2017, Roman, Riker, and Roddissius were all destroyed.
- Rodissius (Leader; formerly)
- Reese (Leader; formerly)
- Roman and Riker
- 8 other shapeshifters